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A detonator system is provided for use with explosives that utilizes two subsystems. A first subsystem functions as a non-explosives based detonator, which does not contain any explosives. The second subsystem is an initiating subsystem, which includes an

Beyond Desensitization: Physiological Relevance of …

Gurevich VV, Pals-Rylaarsdam R, Benovic JL, Hosey MM, Onorato JJ. (1997) Agonist-receptor-arrestin, an alternative ternary complex with high agonist affinity. J Biol Chem 272 :28849–28852 [ PubMed ]

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Similar Meers DF/HCC meers that share similar concepts* with Matthew L. Meyerson, MD, PhD but have yet to coauthor a publiion with this researcher. Research Abstract We work to identify and understand the genomic events that cause human cancers

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Synthetic biology is a relatively new field with the key aim of designing and constructing biological systems with novel functionalities. Today, synthetic biology devices are making their first steps in contributing new solutions to a nuer of biomedical challenges, such as emerging bacterial antibiotic resistance and cancer therapy. This review discusses some synthetic biology approaches and

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Beyond desensitization: physiological relevance of …

28/4/2010· Gurevich VV, Pals-Rylaarsdam R, Benovic JL, Hosey MM, Onorato JJ. (1997) Agonist-receptor-arrestin, an alternative ternary complex with high agonist affinity. J Biol Chem 272:28849–28852 [] [Google Scholar]

Blogography × 2012 × July

— David Simmer II, after realizing NBC time-delayed their Pacific Coast broadcast anyway Saturday, July 28, 2012. 12:05am. I am not a huge sports fan, but I admit to being a fan of the Olympic Games because there''s just something wonderful about the way the world comes together to participate in them.

Endocytosis of G protein-coupled receptors: roles of G …

1/2/2002· Internalization of G protein-coupled receptors is a commonly observed response following agonist-stimulation. For example, the internalization of the prototypical ß 2-adrenergic receptor was initially observed in erythrocytes where the nuer of receptors at the plasma merane decreased upon agonist exposure (Chuang and Costa, 1979a, Chuang and Costa, 1979b).

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The sustainability of interactions between the orexin-1 …

The orexin-1 receptor interacts with β-arrestin-2 in an agonist-dependent manner. In HEK-293T cells, these two proteins became co-internalized into acidic endosomes. Trunions from the C-terminal tail did not prevent agonist-induced internalization of the orexin-1 receptor or alter the pathway of internalization, although such mutants failed to interact with β-arrestin-2 in a sustained

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The sustainability of interactions between the orexin-1 …

1/5/2005· The orexin-1 receptor interacts with β-arrestin-2 in an agonist-dependent manner. In HEK-293T cells, these two proteins became co-internalized into acidic endosomes. Trunions from the C-terminal tail did not prevent agonist-induced internalization of the orexin-1

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Robert J. Lefkowitz’s profile, publiions, research topics, and co-authors The focus of work in this laboratory is on the elucidation of the molecular properties and regulatory mechanisms controlling the function of G protein-coupled receptors.

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29/10/2008· Still cant decide between KAF-8300 and ICX694 - posted in CCD/CMOS Astro Camera Imaging & Processing: Ive read hundreds of posts, looked at hundreds of images, played with CCDCalc for hours, compared technical data, even made a pros and cons list but I cant seem to find that one thing that would tilt the scales in either direction. I have it narrowed down to two specific cameras, the QSI …

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β-Arrestins and Cell Signaling | Annual Review of Physiology

β-Arrestins as Adapters for Internalization β-Arrestins are expressed ubiquitously in all cells and tissues and function in the desensitization of most 7TMRs except rhodopsin. Although their role in the termination of signaling led to their discovery, later research appreciated that β-arrestins serve a second function in receptor internalization [for a review, see Benovic et al. ( 8a ) in

Corrections and Updates

For adapters to attach digital cameras to telescopes, see ScopeTronix. Film photography of the planets is obsolete. Instead, use a video camera with no lens, such as the Meade Lunar-Planetary Imager , a similar Celestron product, or a modified webcam, in place of the telescope eyepiece.

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Handbook of Cell Signaling - SILO.PUB

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Book Review: Arrestin: Roles in the Life and Death of …

Lee KB , Pals-Rylaarsdam R , Benovic JL , Hosey MM . 1998. Arrestin-independent internalization of the m1, m3, and m4 subtypes of muscarinic cholinergic receptors. J Biol Chem 273: 12967-12972. Google Scholar | Crossref | Medline | ISI